In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60758-86-3, name is 3-Ethoxy-4-methoxybenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C10H11NO2
PREPARATION 131(6) To a suspension of lithium aluminum hydride (1.17 g) in anhydrous tetrahydrofuran (15 mL) was added a solution of 3-ethoxy-4-methoxybenzonitrile (2.73 g) in tetrahydrofuran (15 mL). The mixture was stirred for an hour under water cooling and then for an hour at ambient temperature. Potassium sodium (+)-tartrate aqueous solution was added to the mixture under ice-water cooling. The mixture was diluted with ethyl acetate and the insolubles were filtered off. After evaporation of the filtrate, ethyl acetate was added. The solution was dried over magnesium sulfate and evaporated in vacuo to give 3-ethoxy-4-methoxybenzylamine as yellow oil (2.81 g). NMR (CDCl3, delta): 1.47 (3H, t, J=7 Hz), 3.80 (2H, s), 3.87 (3H, s), 4.12 (2H, q, J=7 Hz), 6.80-6.90 (3H, m).
The synthetic route of 60758-86-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6384080; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts