Application of 105942-08-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 105942-08-3 name is 4-Bromo-2-fluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1: Preparation of the starting material: 4-bromo-2-methoxy-benzonitrile. A mixture of 4-bromo-2-fluoro-benzonitrile (15.0 g, 75.0 mmol), methanol (30.4 mL, 350 mmol) and potassium carbonate (31. Ig, 225 mmol) in DMF (150 mL) was stirred under argon at 55 0C overnight. At this point TLC (100percent methylene chloride) revealed no starting material, and the reaction mixture was poured into ether (300 mL) and water (150 mL). The layers were separated, and the organic layer was washed with water (150 mL) and brine (50 mL), dried over Mg2SO4, filtrated, and concentrated under reduced pressure, providing (15.2 g, 95.5percent) of 4-bromo-2- methoxy-benzonitrile as a white solid. 1H-NMR (CDCl3) 7.41 (d, J = 8.1 Hz, IH), 7.16 (dd, J = 8.1, 1,6 Hz, IH), 7.13 (d, J = 1,6 Hz, IH), 3.93 (s, 3H); MS GC-MS (M+ = 211; RT= 6.15 min).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-fluorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; BAYER HEALTHCARE AG; WO2008/25509; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts