Reference of 939-79-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
4-methyl-3- nitrobenzonitrile (Compound 11, manufactured by Tokyo Chemical Industry Co., Ltd.) (965.0 mg, 5.95 mmol) Was dissolved in carbon tetrachloride (10 mL), N-bromosuccinimide (1.270 g, 7.14 mmol) and azobisisobutyronitrile (390.8 mg, 2.38 mmol) were added, and under argon gas atmosphere, 2 And heated under reflux for days. After completion of the reaction, the reaction solution was cooled, water was added, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (eluent: n-hexane / ethyl acetate = 8/1) to obtain Compound 12 (724 mg, 2.99 mmol, yield 50%).
The chemical industry reduces the impact on the environment during synthesis 4-Methyl-3-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NIHON MEDI-PHYSICS COMPANY LIMITED; KYOTO UNIVERSITY; IZAWA, AKIHIRO; OKUMURA, YUKI; KOBASHI, NOBUYA; ABE, TSUTOMU; SAJI, HIDEO; KIMURA, HIROYUKI; (34 pag.)JP2015/93832; (2015); A;,
Nitrile – Wikipedia,
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