Adding a certain compound to certain chemical reactions, such as: 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127946-77-4, name: 1-Amino-1-cyclopropanecarbonitrile hydrochloride
To a two-necked flask was added 1-((tert-butoxycarbonyl) amino) cyclohexanecarboxylic acid (301 mg, 1.24 mmol)1-amino-1-cyclopropyl cyanide hydrochloride (294 mg, 2.48 mmol) HATU (471 mg, 1.24 mmol) and DMF (6 mL), nitrogen protection, at 0C, triethylamine (0.52 mL, 3.72 mmol) was added, the reaction was stirred at 0C for 4 hours. Water (50 mL) was added to the reaction system, extracted with ethyl acetate (50 mL x2) combined organic phase, the organic phase was washed with saturated brine (50 mL x 2) dried over anhydrous sodium sulfate. Filtration, evaporation of the solvent under reduced pressure, the crude product was purified by silica gel column chromatography (petroleum ether / ethyl acetate (V / V) = 8/1), the title compound was obtained as a white solid (0.34 g, 90%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Dongguan Dongyangguang Pharmaceutical Research And Development Co., Ltd.; Zhou Pingjian; Wang Xiaojun; Yang Chuanwen; Lin Jihua; Cao Shengtian; Yang Xinye; Zhang Yingjun; (33 pag.)CN106928113; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts