Electric Literature of 3598-14-9,Some common heterocyclic compound, 3598-14-9, name is Phenoxyacetonitrile, molecular formula is C8H7NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(4) In a 1L hydrogenation tank, 100g of phenoxyacetonitrile and 3g of Raney-Ni, 400mL of ethanol are added and H2 is continuously charged, so that the pressure of the system during the reaction is always maintained at 7MPa. After the reaction was performed at a reaction temperature of 90C for 1 hour, the temperature was lowered. After the temperature in the reactor was lowered to room temperature, the mixture was purged, and phenoxyethylamine (purity of 99% or more) was obtained by filtration and recrystallization. The yield was 93% by weight.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Phenoxyacetonitrile, its application will become more common.
Reference:
Patent; Sinopec Corporation; Sinopec Yangzi Petrochemical Co., Ltd.; Sun Hailong; Wei Yanyu; Gao Yilong; Chen Xinhua; Miao Jun; Li Na; Kan Lin; Bai Jiye; Chen Shaohui; Yang Aiwu; Xu Yuexing; (84 pag.)CN104557610; (2018); B;,
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