Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 179897-89-3, name is 5-Bromo-2-fluorobenzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C7H3BrFN
5-Bromo-2-fluorobenzonitrile (53) (500 mg, 2.54 mmol) was coupled to phenylboronic acid (335 mg, 2.75 mmol) with Cs2CO3 (1.63 g, 5.00 mmol) in toluene (4 mL) in a microwave at 140 C. for 30 minutes. Water was added and the organics extracted several times with EtOAc, dried (MgSO4), filtered and the solvent concentrated in vacuo. The crude product was purified by Flash Master Jones Chromatography using a 25 g silica cartridge and eluting with 10% EtOAc in heptane to yield the title compound. Yield: 375 mg, 76%; LC-MS 41.63 min; HPLC Purity: 97%; MS (ES+) m/z not detectable (M+H)
The synthetic route of 179897-89-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTERAND UK LIMITED; US2010/130556; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts