Reference of 846023-24-3,Some common heterocyclic compound, 846023-24-3, name is 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide, molecular formula is C10H8Cl2N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Isopropanol (80 ml) was added to the reaction flask, and 2-cyano-N- (2,4-dichloro-5-methoxyphenyl) acetamide (10.0 g) and triethyl orthoformate ( 12.03g).The temperature was raised to 80 C, and a solution of isopropylamine (2.4 g) in isopropyl alcohol (60 ml) was added dropwise.Keep stirring for 24h.The system was cooled to room temperature, centrifuged, the solid was dissolved in dichloromethane (130 ml), and separated by column chromatography (n-hexane / ethyl acetate (v / v) = 3: 1) to obtain an off-white solid impurity (I-iPr). .Yield: 94.7%, purity: 99.9%.
The synthetic route of 846023-24-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Wu Yao; Zhou Ting; Jiang Dongdong; Jin Yanfen; Yang Yong; Chen Yu; (16 pag.)CN110372539; (2019); A;,
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