Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 177476-76-5, name is 4-Amino-3-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 177476-76-5
To a solution of 1 (3.46g, 10mmol) in 2-methoxyethanol (20mL) was charged 4-amino-3-methoxybenzonitrile or 4-amino-3-isopropoxybenzonitrile (11mmol) in 2-methoxyethanol (10mL), and the mixture was then heated to 100C, after which methanesulfonic acid (0.64mL, 0.96g, 11mmol) was added dropwise over 5min below 110C, and then the mixture was heated at 110C for 12h. The slurry was cooled to below 10C. The resulting solids were isolated by filtration and washed with cold 2-methoxyethanol until the filtrate was clear to obtain 2a or 2b. 4.1.1.1 4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxybenzonitrile (2a) (0025) Yield: 63.2%; MS (ESI) m/z: 458.3 [M+H]+.
According to the analysis of related databases, 177476-76-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wang, Yu; Chen, Shaowei; Hu, Gang; Wang, Jiao; Gou, Wenfeng; Zuo, Daiying; Gu, Yucheng; Gong, Ping; Zhai, Xin; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 123 – 136;,
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