Related Products of 115279-57-7, A common heterocyclic compound, 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, molecular formula is C10H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 6 (1.0 equiv) in acetic acid (2 mL/1 mmol substrate)AcONa (1.4 equiv) and substituted aniline (1.0 equiv), suchas 2 or 3-trifluoromethylaniline, were added. The resultant mixturewas stirred for 0.5 h at room temperature and quenched withwater. After the rude product was totally precipitated, it was filtered,washed with water and dissolved in DCM. The solutionwas then washed with saturated NaHCO3 solution, brine and driedover anhydrous Na2SO4. Following removal of solvent in vacuo, theresidue was purified via flash column chromatography using EA/PE(1:6) as eluent to afford corresponding ethyl 6-bromo-4-anilino-3-carboxylate quinoline derivative 7a or 7b as light yellow solid. 4.1.4.1 Ethyl 6-bromo-4-((4-(2-cyanopropan-2-yl)phenyl)amino)quinoline-3-carboxylate (7a) Light yellow solid; yield: 83%; ESI-MS: m/z = 438 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Ma, Xiaodong; Lv, Xiaoqing; Qiu, Ni; Yang, Bo; He, Qiaojun; Hu, Yongzhou; Bioorganic and Medicinal Chemistry; vol. 23; 24; (2015); p. 7585 – 7596;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts