Electric Literature of 67832-11-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67832-11-5, name is 4-Bromo-2-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Asolution of nBuLi in THF (2.5 M, 4.49 mL, 11.2 mmol) was added dropwise to astirred solution of 4-bromo-2-methylbenzonitrile (2.0 g,10.2 mmol) in dry THF (100 mL) at -78 C. and the solution stirred at -78 C.for 1 h. A stream of dry CO2 was bubbled through the solution for 10 min andthe mixture warmed to 20 C. The mixture was diluted with water (100 ml) andwashed with Et2O (3¡Á20 mL). The aqueous phase was acidified to pH 2 with cHCland extracted with CHCl3 (3¡Á50 mL) and the organic fraction was dried and thesolvent evaporated to give crude acid 171 (1.05 g, 64%)
The synthetic route of 4-Bromo-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THEBOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLANDUNISERVICES LIMITED; SUTPHIN, PATRICK; CHAN, DENISE; TURCOTTE, SANDRA; DENNY, WILLIAMALEXANDER; HAY, MICHAELPATRICK; GIDDENS, ANNACLAIRE; BONNET, MURIEL; GIACCIA, AMATO; (181 pag.)JP5789603; (2015); B2;,
Nitrile – Wikipedia,
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