Reference of 40497-11-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40497-11-8, name is Ethyl 2,3-dicyanopropanoate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Into a 500 ml three-necked glass bottle, 30.4 g (0.2 mol) of ethyl 2,3-dicyanopropionate (1E) and 300 g of water were sequentially added.The temperature of the reaction solution was lowered to 0 10 with stirring;Add 32g (0.2mol) bromine (Br2) to the reaction solution dropwise, and control the drop rate so that the solution temperature does not exceed 10 ;At the end of the dropwise addition, continue to hold at 0-10 C and stir the reaction for 4h.Then, let stand and dispense. Sampling the organic layer for gas chromatography analysis,The results showed that the content of ethyl 2-bromo-2,3-dicyanopropionate (1F), the target product of this reaction, was 91.22%, and it could be directly put into the next reaction.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2,3-dicyanopropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiangsu Guangyu Chemical Co., Ltd.; Shi Haibing; Song Qifa; Cai Yichao; (8 pag.)CN111004250; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts