Electric Literature of 14618-78-1, A common heterocyclic compound, 14618-78-1, name is 4,4-Dimethoxybutanenitrile, molecular formula is C6H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 68 2-formyl-4,4-dimethoxybutanenitrile Lithium diisopropylamide mono(tetrahydrofuran) (1.5 M in cyclohexane, 22.0 mL, 33.00 mmol) was added to THF (100 mL) at -30 C. and the resulting solution was stirred for 10 min before 3-cyanopropionaldehyde dimethyl acetal (3.90 mL, 29.90 mmol) was added dropwise over 5 min. After 15 min, methyl formate (2.80 mmol, 45.42 mmol) was added and the resulting solution was stirred at -20 C. to -15 C. for 2 h. The reaction mixture was quenched with water (100 mL) and washed with ether (2*50 mL, discarded). The aqueous layer was acidified with 10% HCl and extracted with ether (3*50 mL). The combined ether extracts were washed with brine (3*50 mL), dried (MgSO4), and concentrated. The residue was dissolved in dichloromethane and concentrated to remove traces of THF and provide 2.28 g (49%) of the title compound as a pale yellow oil.
The synthetic route of 14618-78-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ortho-McNeil Pharmaceutical, Inc.; US6613747; (2003); B2;; ; Patent; Henninger, Todd C.; Xu, Xiaodong; US2002/115620; (2002); A1;,
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