Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 114344-60-4, name is 2-Amino-3-bromobenzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 2-Amino-3-bromobenzonitrile
xample 11 – Synthesis of Compound 15; A solution of 1.39 g (7.04 mmol) 2-amino-3-bromo-benzonitrile (synthesis described in J. B. Campbell and T. W. Davenport, Syn. Commun. 19, 2255 [1989]) in 14 ml 1 – butanol was treated with 1.14 g (14.1 mmol) triazine and 1.2 ml acetic acid and heated to 110 C. The resulting solution was stirred for 4 days at this temperature. The reaction mixture was cooled to room temperature and evaporated. The residue was crystallized from tert.butyl-methyl-ether yielding 8-bromo-quinazolin-4-ylamine as brown solid; HPLC/MS: 1.00 min, [M+H] 224/226
The synthetic route of 114344-60-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; DORSCH, Dieter; JONCZYK, Alfred; HOELZEMANN, Guenter; AMENDT, Christiane; ZENKE, Frank; WO2012/595; (2012); A1;,
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