606080-43-7, name is Methyl 2-cyano-5-fluorobenzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks
b) Synthesis of 2-Cyano-5-dimethylamino-benzoic acid methyl ester (21b). To a stirred solution of 4.03 g (22,5 mmol) 21a and 60.0 ml dimethylsulphoxid are added 2.23 g (27.0 mmol) dimethylamine hydrochloride and 6.54 g (47.3 mmol) potassium carbonate. The reaction mixture is stirred for 15h at 65C in an autoclave and is reduced with high vacuum rotation evaporator at 65C. The residue is diluted with dichloromethane, washed twice with water. The combined water phases are extracted with dichloromethane. The combined dichloromethane phases are washed with diluted sodium hydrogen carbonate solution, dried with sodium sulphate and concentrated. The oily crude is purified by column chromatography and the desired product 21b is obtained in 89.0 % yield (4.09 g, 20.0 mmol). MS-ESI: 205 (M+ +1, 100),
The synthetic route of 606080-43-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer Schering Pharma Aktiengesellschaft; EP1897885; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts