Related Products of 628-20-6,Some common heterocyclic compound, 628-20-6, name is 4-Chlorobutyronitrile, molecular formula is C4H6ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixtureof aziridine 1 (0.25 mmol), nitrile 2 or 4 (0.25 mmol) and perchloric acid(0.25 mmol) was placed in a mortar. The reaction mixture was thoroughlyground at room temperature for 5 min. After completion (TLC) the reactionmixture was diluted with a 1 : 1 water/ethyl acetate mixture (10 ml) andwashed with sodium bicarbonate (10 ml) followed by brine solution (10 ml).Then the combined organic layer was dried over anhydrous Na2SO4.Evaporation of solvent furnished the crude product which was subjectedto column chromatography using ethyl acetate-light petroleum as eluentto obtain the analytically pure product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chlorobutyronitrile, its application will become more common.
Reference:
Article; Charushin, Valery N.; Chupakhin, Oleg N.; De, Aramita; Kopchuk, Dmitry S.; Kovalev, Igor S.; Majee, Adinath; Santra, Sougata; Zyryanov, Grigory V.; Mendeleev Communications; vol. 30; 2; (2020); p. 188 – 189;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts