Synthetic Route of 623-03-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 623-03-0 as follows.
Under a nitrogen atmosphere, a reaction vessel of 20 ml in volume was charged with bis(pinacolate)diboron (1.1 Ig (4.4 mmol)), degassed methanol (7.2 g) and diisopropylethylamine (1.13 g (8.7 mmol)) and stirred at room temperature. The reaction vessel was charged with bis(l,5-cyclooctadiene)nickel (32 mg (0.12 mmol)), triphenylphosphine (61 mg (0.23 mmol)), and 4-chlorobenzonitrile (0.40 g (2.9 mmol)) and stirred at 3O0C for 21 hours, and thereafter stirred at 500C for 3 hours. The reaction solution was analyzed by gas chromatography. As a result, 4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)benzonitrile was contained in an amount of 0.58 g(2.6 mmol, yield: 88%).
According to the analysis of related databases, 623-03-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; GENENTECH, INC.; MIKI, Takashi; SHIMASAKI, Yasuharu; BABU, Srinivasan; CHENG, Zhigang; REYNOLDS, Mark, E.; TIAN, Qingping; WO2010/110782; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts