Related Products of 139152-08-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139152-08-2 name is 4,5-Dichlorophthalonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4,5-Dichlorophthalonitrile (1g, 5.07 mmol) and 1,3-diazido-2-propanol (721 mg, 5.07 mmol) were dissolved in 50 mL anhydrous DMF. After stirring, anhydrous K2CO3 (1.05 g, 7.61 mmol) was added dropwise to solution over 30 minutes with continued stirring. Then the reaction mixture was stirred at 70 C for 72 h under argon atmosphere. After this time, the reaction mixture was cooled to room temperature and poured into ice-water. The formed crude product was filtered, washed with water and dried with vacuo. Then the product was purified by column chromatography on silicagel using hexane-ethyl acetate (60:40) solvent system as eluent (Rf = 0.40). Yield: 1.2 g (78%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,5-Dichlorophthalonitrile, and friends who are interested can also refer to it.
Reference:
Article; Sari, Sait; Durmu?, Mahmut; Bulut, Mustafa; Tetrahedron Letters; vol. 57; 10; (2016); p. 1124 – 1128;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts