Synthetic Route of 501420-63-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 501420-63-9 as follows.
To a stirred suspension of NaH (16.3 g, 406 mmol, 3 eq) in anhyd THF (100 mL) at 0 0C was added dropwise a solution of 2-(3-bromo-4-fluorophenyl)acetonitrile (29 g, 135 mmol) in anhyd THF (200 mL). After stirring Ih, MeI (42.1 mL, 675 mmol, 5 eq) was added to the reaction mixture. After stirring 2h at 0 0C, the reaction was allowed to warm to room temperature, quenched carefully with H2O and extracted with EtOAc. The combined extracts were washed with brine, dried over MgSO4 and evaporated in vacuo to give 2-(3-bromo-4- fluorophenyl)-2-methylpropanenitrile (29 g, 88%). 1H NMR (400 MHz, CDCl3) delta 7.66-7.64 (m, IH), 7.44-7.40 (m, IH), 7.15 (t, J=8.4 Hz, IH), 1.72 (s, 6H).
According to the analysis of related databases, 501420-63-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin; WO2010/93845; (2010); A1;,
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