Synthetic Route of 21667-62-9,Some common heterocyclic compound, 21667-62-9, name is 3-(3-Chlorophenyl)-3-oxopropanenitrile, molecular formula is C9H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred suspension of LAH (16 g, 90 mmol) in dry THF (200 mL) was added a solution of 3-(3-chlorophenyl)-3-oxopropanenitrile (10.4 g, 270 mmol) in dry THF (200 mL) dropwise at 0 C. under nitrogen atmosphere. The mixture was warmed to 25 C. and then heated at 60 C. for 3 hours. After cooling to 0 C., a saturated solution of sodium hydroxide was added dropwise and extracted with ethyl acetate (200 mL). The solution was dried over anhydrous sodium sulfate and concentrated to dryness. The crude 3-amino-1-(3-chloro-phenyl)-propan-1-ol obtained was used in the next step without further purification. (Yield 14.5 g, crude). LC-MS: [M+H]+ 186.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(3-Chlorophenyl)-3-oxopropanenitrile, its application will become more common.
Reference:
Patent; Luk, Kin-Chun; US2012/184562; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts