Electric Literature of 3672-47-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2 (2.0 g, 11.4 mmol), N,N-diethylchloroacetamide (1.7 g, 11.4 mmol) and NaI (5.1 g, 34 mmol) were added to a solution of NaOH (0.5 g, 12.5 mmol) in 80% EtOH (80 ml) whilst being stirred continuously. The mixture was stirred at room temperature for 7 hours and monitored by t.l.c. Once the reaction was complete it was allowed to cool and was filtered to remove the inorganic material. The filtrate was concentrated and the residue was purified by column chromatography (CH2Cl2 as eluent) to yield 3 (2.1 g, 64 %) as a dark yellow oil; 1H n.m.r. (CDCl3, 300 MHz) delta 1.06-1.30 (m, 6H, N(CH2CH3)2), 2.85 (dd, J= 4.5, 16.2 Hz5 IH, CH2), 3.21-3.43 (m, 5H: 4H, N(CH2CH3)2 : IH, CH2), 3.90 (s, 3H, OCH3), 4.89-5.02 (m, IH, CH), 6.98 (d, J= 8.7, 2H5 Ph)5 8.05 (d, J= 9.O5 2H, Ph). Mass Spectrum: CI5 m/z 289 (M + 1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methoxyphenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE UNIVERSITY OF SYDNEY; WO2007/134362; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts