Related Products of 135748-35-5, These common heterocyclic compound, 135748-35-5, name is 4-Chloro-2,5-difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
b [3-(5-Chloro-2-cyano-4-fluorophenoxy)-3-cyclopentylpropyl]methylcarbamic Acid, 1,1-dimethylethyl Ester The subtitle compound was prepared according to the method of Example 3 step (b) using (3-cyclopentyl-3-hydroxypropyl)methylcarbamic acid, 1,1-dimethylethyl ester and 4-chloro-2,5-difluorobenzonitrile in N,N-dimethylformamide. 1H NMR 300 MHz (CDCl3) 7.32 (1H, d), 7.04 (1H, bm), 4.28 (1H, m), 3.35 (2H, bm), 2.83 (3H, s), 2.28 (1H, m), 1.95 (2H, q), 1.50-1.80 (6H, m), 1.42 (9H, s), 1.26-1.45 (2H, m).
Statistics shows that 4-Chloro-2,5-difluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 135748-35-5.
Reference:
Patent; Cheshire, David; Connolly, Stephen; Cox, David; US2003/65174; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts