These common heterocyclic compound, 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C11H13NO3
Following procedures similar to that of Step D but substituting 3,4,5-trimethoxyphenylacetonitrile for 3-methoxy-5-(methylthio)-4-propoxyphenylacetonitrile, there was prepared ethyl 3,4,5,-trimethoxy-alpha-cyanobenzeneacetate in 89% yield as a clear oil. NMR (CDCl3): delta 1.35 (t, 3H, -CO2CH2C H 3), 4.25 (q, 2H, -CO2C H 2CH3), 4.65 (s, 1H, -C H (CN)CO2Et), 6.05 (s, 2H, Ar-H).
The synthetic route of 3,4,5-Trimethoxyphenylacetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck & Co., Inc.; EP257921; (1988); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts