Some common heterocyclic compound, 147754-12-9, name is 4-Fluoro-2-methylbenzonitrile, molecular formula is C8H6FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H6FN
[0144] 4-Fluoro-2-methylbenzonitrile (2.9g), 5N NaOH (50 mL), and MeOH (50 mL) were set stirring at 100 ¡ãC for 18 hours. The solvent was removed under reduced pressure and the product was washed with CH2CI2 and acidified to pH 1. The reaction was partitioned between ethyl acetate and water and the organic layer was washed with brine and dried overanhydrous Na2S04 to yield a while solid (1.6 g). *H NMR (300 MHz, CDC13): 5 8.07-8.14 (m, 1H), 6.96-7.01 (m, 1H), 6.79-6.82 (m, 1H), 2.73 (br s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 147754-12-9, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts