Reference of 90381-43-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 90381-43-4, name is 7-Methoxy-2-naphthonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Preparative Example 6 7-Cyano-2-methoxy-1-naphthaldehyde STR28 Under nitrogen atmosphere, 3.7 g of 2-cyano-7-methoxynaphthalene was dissolved in 40 ml of dichloro-methane, and 6.6 ml of titanium tetrachloride and 4.6 ml of dichloromethyl methyl ether were added dropwise into the resulting solution at 0 C. in this order. The resulting mixture was stirred at room temperature for 30 minutes and cooled to 0 C. again. Water was added to the resulting mixture to cease the reaction, and the resulting mixture was extracted with dichloromethane (100 ml*2). The organic layers were combined, washed with water, da saturated aqueous solution of sodium bicarbonate and brine successively, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated and the resulting crude crystal was washed with ether and dried to give 3.3 g of the title compound as colorless crystals. 1 H–NMR (CDCl3, 400 MHz) delta; 4.10(s,3H), 7.48(d,1H, J=8.8 Hz), 7.57(dd,1H, J=1.2,8.4 Hz), 7.86(d,1H,J=8.4 Hz), 8.11(d,1H,J=8.8 Hz), 9.74(s,1H), 10.87(s,1H).
The synthetic route of 7-Methoxy-2-naphthonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai Co., Ltd.; US6110959; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts