These common heterocyclic compound, 628-20-6, name is 4-Chlorobutyronitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Chlorobutyronitrile
1L three-necked flask 600ml of anhydrous ethanol under ice four hours continuously fed ammonia to saturation;pressurized cylinders ethanol was added a saturated solution of ammonia had been prepared, and then added 103.5g 4-chlorobutyronitrile (lmol), sealed in an oil bath heated 100-120 C, 10 hours;After completion of the reaction, cooled to room temperature, the reaction solution was spin to 70% ethanol, the precipitated solid was filtered, and the mother liquor was recrystallized with ether to give a solid, solids were combined to give a pale yellow solid drying 89.2g,No. HHC-014-A, Yield 74%
The synthetic route of 4-Chlorobutyronitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Pharmatechs Co., Ltd; Zhang, Xiaowen; Yang, Jie; (5 pag.)CN103435617; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts