In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54454-12-5 as follows. COA of Formula: C8H6ClN
EXAMPLE 37 Cis-2-(3-chloro-o-toluoyl)-3-hydroxycrotononitrile A 4.5 g. portion of potassium tertiary butoxide is added to 700 ml. of ether and then cooled in an ice-salt bath. To this is added, over 15 minutes, a mixture of 60.0 g. of 3-chloro-2-methylbenzonitrile and 22.0 ml. of acetonitrile in 300 ml. of ether. The mixture is stirred in the ice bath for 1/2 hour, allowed to warm to room temperature and then stirred for one hour. This mixture is poured into one liter of water and the layers are separated. The aqueous phase is extracted with ether and the ether layers are combined, washed four times with water and dried over magnesium sulfate. The crystals which form on evaporation are collected and recrystallized from 200 ml. of hot benzene giving 16.0 g. of beta-amino-3-chloro-2-methylcinnamonitrile. An 11.0 g. portion of the above product is added to 150 ml. of methanol and heated to solution on a steam bath.
According to the analysis of related databases, 54454-12-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; American Cyanamid Company; US4173650; (1979); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts