Adding a certain compound to certain chemical reactions, such as: 147754-12-9, name is 4-Fluoro-2-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 147754-12-9, SDS of cas: 147754-12-9
The 4- Fluoro-2-methylbenzonitrile (compound B)(2g,14.8mmol) , N-Bromosuccinimide(NBS) (2.64g,15mmol) , AzobisisobutyronitrileAIBN(100mg) dissolved in CCl4 , Under theprotection of nitrogen gas it was heated to reflux for 2 h. Cooled toroom temperature, filtered to remove solids, concentrated to obtain crude oil, Which was used directly in the nextstep without purification.
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Reference:
Patent; Hebei Guolong Pharmaceutical Co.,Ltd; Yin, Dian Shu; Du, Yu Min; Wang, yabo; Wei, Sai Li; Shang, weiding; Zhao, yisha; Yan, Yong-Na; Zhang, qingjiang; Wang, Chun FA; (13 pag.)CN105541793; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts