Electric Literature of 59997-51-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59997-51-2 name is 4,4-Dimethyl-3-oxopentanenitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 22. Preparation of Compound Nos. 142, 142a and 142b Step 2. To a solution of 4,4-dimethyl-3-oxopentanenitrile (2.22 g, 19.79 mmol) in ethanol (25 mL) was added hydrazine hydrate (1.06 g, 21.37 mmol) at 0 C. The reaction mixture was stirred at 100 C for 16 h. The reaction mixture was concentrated to remove the solvent, diluted with water, extracted with EtOAc (300 mL X 3). The combined organic layers were dried over anhydrous sodium sulfate, concentrated under reduced pressure to afford 5-(tert-butyl)-lH-pyrazol-3-amine (1.3 g, crude).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,4-Dimethyl-3-oxopentanenitrile, and friends who are interested can also refer to it.
Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; CHAKRAVARTY, Sarvajit; RAI, Roopa; GREEN, Michael, John; ANSARI, Amantullah; AGARWAL, Anil, Kumar; (216 pag.)WO2016/3827; (2016); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts