Electric Literature of 42872-83-3, These common heterocyclic compound, 42872-83-3, name is 2-Bromo-5-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Ni NPs/HT (0.05 g) is placed in a heavy-walled pressure tube, followed by the addition of water (4 ml) and benzonitrile (1 mmol), and the reaction mixture is vigorously stirred at 120 C in an oil bath for the specified time in tables. The progress of the reaction in each case was monitored by TLC analysis. After completion of the reaction, the reaction mixture is extracted with ethyl acetate, after the extraction, the catalyst is removed by filtration, and the filtrate is cooled to 0 C, and white crystals are precipitated from the filtrate. The crystalline product was obtained by simple filtration and dried in vacuo at room temperature to give analytically amide product. In cases where the product not precipitated out, the reaction mixture was extracted with ethyl acetate, subsequent purification by column chromatography on silica gel provided amide product.
The synthetic route of 42872-83-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Subramanian, Thirumeni; Pitchumani, Kasi; Catalysis Communications; vol. 29; (2012); p. 109 – 113;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts