These common heterocyclic compound, 950596-58-4, name is 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 950596-58-4
General procedure: A mixture of 3 (2.00mmol), toluene (5mL), and DMF-DMA (4.00mmol) were heated up to 35-40C and acetic acid (0.10mL) was added. After 15min, the resultant mixture was cooled to approximately 25C. The solvent was completely evaporated. The residue was added to water and basified pH to 13 by the addition of 20% sodium hydroxide. The obtained mixture was extracted with methylene chloride (2¡Á15mL) and the combined organic extracts were washed with water (2¡Á20mL) and brine (1¡Á70mL), then dried over anhydrous MgSO4. The organic solvent was evaporated to give 4 as oil (Yield 61-94%).
The synthetic route of 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Li; Zhang, Yaling; Liu, Juan; Wang, Weijia; Li, Xiabing; Zhao, Lijun; Wang, Wei; Li, Baolin; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 689 – 697;,
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