A new synthetic route of 194853-86-6

Application of 194853-86-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 194853-86-6 as follows.

EXAMPLES; Example 1; 4-[(Cyclopropylmethyl)(2-{[4-(1 ,1 -dimethylethyl)phenyl]oxy} ethyl)amino]-2- (trifluoromethyl)benzonitrile; A. 4-[(Cyclopropylmethyl)amino]-2-(trifluoromethyl)benzonitrile; A mixture of 4-fluoro-2-(trifluoromethyl)benzonitrile (9.45 g, 50 mmol), 1- cyclopropylmethanamine (5.0 g, 70 mmol), and potassium carbonate (10 g) was stirred for 12 h in acetonitrile (50 mL) at 55 0C. The mixture was cooled to 20 0C, filtered, and the filter-cake was washed with acetonitrile (3 x 25 mL). The filtrate was concentrated under vacuum to obtain 11.9 g (99%) of the title compound as a white EPO solid: 1H NMR (400 MHz, CDCI3) delta 7.53 (d, J = 8.6 Hz, 1 H), 6.83 (d, J = 2.4 Hz, 1 H), 6.65 (dd, J = 8.6, 2.4 Hz, 1H)1 4.62 (bs, 1 H), 3.02 (d, J = 7.1 Hz, 2H), 1.09 (m, 1 H), 0.61 (m, 2H), 0.27 (m, 2H).

According to the analysis of related databases, 194853-86-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/44707; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts