Reference of 1250444-23-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1250444-23-5, name is 3-Bromo-2,6-difluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
3-bromo-2,6-difluorobenzonitrile and triethyl phosphite were fed at a ratio of 1: 8.0, N2 was protected, reacted The temperature is 100 C and the reaction is carried out under light conditions. TLC was monitored and reacted for 30 h until the feed point disappeared. The product is decompressed Distillation, the oil bath temperature to 10 C, steaming low boiling point fraction. The product was again subjected to vacuum distillation at an oil bath temperature of 190 C and steamed A high boiling fraction is taken and the fraction is taken at a temperature of 135-145 C. The distillate is dissolved in ethyl acetate and treated with 10% Na2C03, saturated sodium chloride, washed with anhydrous magnesium sulfate, filtered and evaporated to give a yellow oily liquid product in 83% yield.
The chemical industry reduces the impact on the environment during synthesis 3-Bromo-2,6-difluorobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Tianjin Normal University; Song, fanbo; Zhang, ZhongBiao; Li, huayun; Tang, hongying; Wang, ZhiJiang; Song, AiRu; (8 pag.)CN104017021; (2016); B;,
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