In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4640-66-8, name is 4-Chlorophenacylcyanide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C9H6ClNO
In a 25 mL reaction tube with a Teflon magnetic stir bar,Add 0.5 mmol of 3-(4-chlorophenyl)-3-oxopropanenitrile, 0.5 mmol of 3-bromo-1,1,1-trifluoroacetone, 0.5 mmol of sodium acetate,Finally, 58 mmol of 1,4 dioxane was added, and the reaction was stirred at room temperature for 8 hours.Add 15 mL of water, extract three times with 10 mL of ether, and combine the organic phases.Washing with saturated sodium chloride solution, drying over anhydrous magnesium sulfate, and then removing the organic solvent by rotary evaporation;The obtained crude product was eluted with n-pentane and ethyl acetate (10:1, v/v).5-Hydroxy-2-(4-chlorophenyl)-5-(trifluoromethyl)-4,5-dihydrofuran-3-carbonitrile (isolated yield 60%) was obtained by silica gel column chromatography.
The synthetic route of 4640-66-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fuzhou University; Weng Zhiqiang; Wang Junwen; (29 pag.)CN110272400; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts