Adding a certain compound to certain chemical reactions, such as: 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3672-47-7, Application In Synthesis of 3-(4-Methoxyphenyl)-3-oxopropanenitrile
2. Synthesis of Intermediate 2:Sodium hydroxide (1.76 g, 44 mmol)Was dissolved in 140 mL of 80% aqueous ethanol,1 (7 g, 40 mmol) was added to the reaction flask,N, N-diethylchloroacetamide (5.98 g, 40 mmol),Sodium iodide (14.99 g, 100 mmol).Room temperature reaction for 12 hours.The solvent was distilled off under reduced pressure,To the residue was added 100 mL of saturated brine and 200 mL of ethyl acetate,After thorough mixing,Separate the organic layer,Dried over anhydrous sodium sulfate,Concentrated, column chromatography,To give product 2 (7.72 g, 67%) as a red oil.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; Xiamen University Affiliated Zhongshan Hospital; Su Xinhui; Wang Liangliang; Li Yesen; Guo Zhide; Zhang Xianzhong; Chen Lichun; (18 pag.)CN106749279; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts