Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21423-84-7, name is 2-Chloro-4-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Chloro-4-methylbenzonitrile
4-(Bromomethyl)-2-chlorobenzonitrile (Intermediate h) [00161] To a solution of 44 (160 mg, 1.05 mmol) in CCLI (5 mL) was added NBS (224 mg, 1.26 mmol), AIBN (183 mg, 1.05 mmol). The mixture was stirred at 70 C for 6 h. The mixture was concentrated under reduced pressure. The residue was purified by preparative TLC (petroleum ether / ethyl acetate = 10:1) to give intermediate h (110 mg, 45%) as a white solid.
According to the analysis of related databases, 21423-84-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; DILLARD, Lawrence, Wayne; DONG, Chengguo; FAN, Yi; JIA, Lanqi; LOTESTA, Stephen, D.; MARCUS, Andrew; SINGH, Suresh, B.; TICE, Colin, M.; YUAN, Jing; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; WO2014/179564; (2014); A1;,
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