Adding a certain compound to certain chemical reactions, such as: 288251-96-7, name is 2-Isobutyl-5-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288251-96-7, name: 2-Isobutyl-5-nitrobenzonitrile
To a solution of 2-isobutyl-5-nitrobenzonitrile (D56) (7.5 g) in methanol (80 mL) and water (80 mL) was added ammonium formate (51.9 g) and zinc (26.9 g). The reaction mixture was stirred at 80 C for 4 h. After cooling the reaction, the solid was filtered, the filtrate was concentrated under reduced pressure, the residue was extracted with EtOAc(300mL*2), the combined organic layers were washed with water (30mL*2), dried and concentrated to give 5-amino-2-(2- methylpropyl)benzonitrile (D57) (17.5 g) as a colorless solid. MS (ES): CnH14N2 requires 174; found 175.1 (M+H+).
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Reference:
Patent; GLAXO GROUP LIMITED; DENG, Guanghui; LIN, Xichen; REN, Feng; ZHAO, Baowei; WO2011/134280; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts