Adding a certain compound to certain chemical reactions, such as: 243128-37-2, name is 4-Fluoro-3-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 243128-37-2, Quality Control of 4-Fluoro-3-methoxybenzonitrile
Example Al a) Preparation of intermediate 1. K2CO3 (112 g, 0.81 mol) was added to a stirred sol. of 4-methylimidazole (66.0 g, 0.804 mol) in DMSO (600 ml). The r.m. was heated at 120 0C. Subsequently 4-fluoro- 3-methoxybenzonitrile (60.0 g, 0.397 mol) was added portionwise (internal reaction temperature increased to 140 0C). The r.m. was maintained at 120 0C for 1 h, was cooled, and was then poured onto ice-water (3 1). This mixture was stirred for 30 min. The precipitated solid was collected by filtration and washed with H2O. The off-white solid was recrystallised from MeCN to yield 30.0 g of intermediate 1. A second crop of product was obtained from the mother liquor. Yield: 12.3 g of intermediate 1(combined yield; 49.9 %).
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Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; WU, Tongfei; GIJSEN, Henricus, Jacobus, Maria; ROMBOUTS, Frederik, Jan, Rita; BISCHOFF, Francois, Paul; BERTHELOT, Didier, Jean-Claude; OEHLRICH, Daniel; DE CLEYN, Michel, Anna, Jozef; PIETERS, Serge, Maria, Aloysius; MINNE, Garrett, Berlond; VELTER, Adriana, Ingrid; VAN BRANDT, Sven, Franciscus, Anna; SURKYN, Michel; WO2011/6903; (2011); A1;,
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