Synthetic Route of 7153-22-2,Some common heterocyclic compound, 7153-22-2, name is Ethyl 4-cyanobenzoate, molecular formula is C10H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of hydroxylammonium chloride (1 eq.) in absolute ethanol (0.75 M) triethylamine (1 eq.) and starting compound (21 or 22) were added. The resulting solution was stirred at 60 C for 15 h. The solvent was removed under reduced pressure and residue dissolved in EtOAc, which was further washed with saturated solution of NaHCO3 and brine. The organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure to give product 23 or 24.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-cyanobenzoate, its application will become more common.
Reference:
Article; Trstenjak, Uro?; Ila?, Janez; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 302 – 313;,
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