Adding a certain compound to certain chemical reactions, such as: 939-83-3, name is 2-Methyl-5-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-83-3, Computed Properties of C8H6N2O2
A mixture of 2-cyano-4-nitrotoluene (10 g, 6.17 mmol), benzaldehyde (6.51 g, 6.17 mmol) and potassium carbonate (20 g) in MeOH (200 mL) was heated at reflux for 10 min. The mixture was cooled to ambient temperature over 30 min, whereupon precipitation of the product was complete. The product was isolated by filtration and washed successively with 1N HCl, water and MeOH then air dried. There was obtained 13.0 g of the benzamide (mp 269.8 C.) as evident from the lack of a nitrile adsorption in the IR and the appearance of peaks at 3357.1, 3193.6 (-NH2) and 1648.7 cm-1 (H2NC(O)-); LRMS (M-NO)+ m/z=238.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methyl-5-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DuPont Pharmaceuticals Company; US6339099; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts