Application of 34403-48-0, A common heterocyclic compound, 34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, molecular formula is C9H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-(methylaminomethyl)benzonitrile (5.0 g, 1 eq.) and triethylamine (8.65g, 2.5 eq.) in dichloromethane (100 ml.) was added 2,2,2-trifluoroethanesulfonyl chloride (0520) (7.49 g, 1 .2 eq.). The mixture was stirred at room temperature for two hours. Then ethyl acetate was added, the organic layer was washed with water, dried over sodium sulfate and (0521) concentrated in vacuo to yield the title compound (10.4g) as yellow solid witch was used without further purification
The synthetic route of 34403-48-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; TERTERYAN-SEISER, Violeta; GRAMMENOS, Wassilios; QUINTERO PALOMAR, Maria Angelica; CRAIG, Ian Robert; WIEBE, Christine; MENTZEL, Tobias; FEHR, Marcus; ESCRIBANO CUESTA, Ana; WINTER, Christian Harald; LOHMANN, Jan Klaas; MUELLER, Bernd; GROTE, Thomas; CAMBEIS, Erica; (62 pag.)WO2018/114393; (2018); A1;,
Nitrile – Wikipedia,
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