Reference of 107-91-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 107-91-5 as follows.
Add 13.8 g (0.1 mol) to a 250 mL three-necked bottlePotassium carbonate, dissolved in 100 mL of water, added 11.0 g (0.1 mol)Acetylacetone, 8.4 g (0.1 mol) of cyanoacetamide was added in portions at room temperature.During the feeding process, the temperature slowly rises by about 10 C.A large amount of solid precipitated out as the reaction proceeded. After 24 h, the reaction was stopped by TLC (MeOH: DCM = 1: 20) and filtered.The filter cake was washed three times with water.Dry to give 14 g of a white solid.The solid was recrystallized from 1 L of methanol.13.0 g of a white needle-like solid was obtained in a yield of 87.8%.
According to the analysis of related databases, 107-91-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shenyang Pharmaceutical University; Chen Guoliang; Wang Lihui; Zhou Qifan; Du Fangyu; Dong Xiaoyu; Yang Jingyu; Wu Chunfu; (48 pag.)CN109320499; (2019); A;,
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