In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1009-35-4 as follows. Quality Control of 4-Fluoro-3-nitrobenzonitrile
10623] To a stirred solution of 4-fluoro-3-nitrobenzonitrile (1 g, 6.02 mmol) in CH2C12 (5 mE) was added potassium carbonate (1.66 g, 12.05 mmol) followed by cyclopropanamine (3.33 mE, 48.19 mmol) dropwise at 0¡ã C. under an inert atmosphere. The reaction mixture was gradually warmed to room temperature and stirred for 4 h. After consumption of starting material (by TEC), the reaction mixture was poured into water (30 mE) and extracted with EtOAc (2×50 mE). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 4-(cyclopropylamino)-3-ni- trobenzonitrile (1.1 g) as a yellow solid. The crude material was taken to the next step without further purification.10624] ?H NMR (400 MHz, CDC13): oe 8.49 (d, J=1.9 Hz,1H), 8.41 (brs, 1H), 7.66-7.63 (m, 1H), 7.40 (d, J=9.0 Hz,1H), 2.68-2.61 (m, 1H), 1.04-0.98 (m, 2H), 0.75-0.70 (m,2H)10625] EC-MS: m/z 202.0 [M?H] at 2.88 RT (99.48percent purity)
According to the analysis of related databases, 1009-35-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; Hoekstra, William J.; (156 pag.)US2018/185362; (2018); A1;,
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