Synthetic Route of 612-24-8, A common heterocyclic compound, 612-24-8, name is 2-Nitrobenzonitrile, molecular formula is C7H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Nitrobenzene (0.6mmol), 5wt% Pd/C (0.5mmol %, 0.003mmol), H2O (10 equiv, 6.0mmol), B2(OH)4 (3.3 equiv, 2.0mmol), and CH3CN (1.0mL) were added in a 10mL tube. The reaction mixture was stirred at 50C for 24h. When the reaction was complete monitored by TLC, the mixture was cooled to room temperature. Water (5mL) was added, and extracted with EtOAc (3¡Á5mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give aniline 2a (55mg, 99%).
The synthetic route of 612-24-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhou, Yanmei; Zhou, Haifeng; Liu, Sensheng; Pi, Danwei; Shen, Guanshuo; Tetrahedron; vol. 73; 27-28; (2017); p. 3898 – 3904;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts