67832-11-5, name is 4-Bromo-2-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-Bromo-2-methylbenzonitrile
Example 1: Synthesis of 4-{4-{1-hydroxyethyl)pyridin-3-yl)-2-methylbenzonitrileStep 1: 2-methyl-4-(4,4,5l5-tetramethyl-1 ,3 2-dioxaborolan-2-yl)benzonitrile (1a)A mixture of 4-bromo-2-methylbenzonitrile (1 g, 5.10 mmol), bis(pinacolato)diboron (1.554 g, 6.12 mmol), potassium acetate (1.001 g, 10.20 mmol) and PdCI2(dppf).CH2CI2 adduct (0.208 g, 0.255 mmol) in 1 ,4-Dioxane (12.75 ml) was heated to 80 C for 5 hr. The mixture was concentrated, and the residue was purified via Biotage (0-10% EtOAc/heptane; SNAP50 column) giving compound 1 as white solid (860 mg, 69%). 1H NMR (400 MHz, CDCI3) delta ppm 1.28 (s, 12 H) 2.38 – 2.52 (m, 3 H) 7.51 (d, J=7.64 Hz, 1 H) 7.55 – 7.64 (m, 1 H) 7.67 (s, 1 H).
The synthetic route of 67832-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; ALLAN, Martin; CHAMOIN, Sylvie; HU, Qi-Ying; IMASE, Hidetomo; PAPILLON, Julien; WO2011/61168; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts