In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34916-10-4 as follows. Formula: C7H9NO
To a stirred solution of R-06i-3 (4.00 g, 32.48 mmol) and KHMDS (1 .0 M, 42.87 mL, 42.87 mmol) in THF (200 mL) under N2at -78 C was added PhNTf2(14.85 g, 41 .57 mmol) and the reaction mixture was stirred at 20 C for 8 hours. Then, the mixture was cooled to 20 C and concentrated in reduced pressure at 40 C. The residue was poured into water and extracted with ethyl acetate. The combined organic phase was washed with brine, dried with anhydrous Na2S04, filtered and concentrated in vacuum. The residue was purified by column chromatography (Si02, Petroleum ether/Ethyl acetate = 50/1 to 1 :1 ) to give R-06i- 4 (3.00 g, 36%) as a colorless oil. ESI-MS (M+1 ): 256.1 calc. for C8H8F3N03S: 255.0.
According to the analysis of related databases, 34916-10-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FUNDACION PARA LA INVESTIGACION MEDICA APLICADA; AGUIRRE ENA, Xabier; OYARZABAL SANTAMARINA, Julen; PROSPER CARDOSO, Felipe; RABAL GRACIA, Maria Obdulia; SAN JOSE ENERIZ, Edurne; SANCHEZ ARIAS, Juan Antonio; VILAS ZORNOZA, Amaia; (96 pag.)WO2018/229139; (2018); A1;,
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