Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 263159-64-4, name is 2-Bromo-3-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H6BrN
To a solution of 2-bromo-3-methylbenzonitrile (12 g, 51 mmol, 1.0 eq) in tetrachloromethane (127.5mL) was added N-bromosuccinimide (10 g, 56.1 mmol, 1.1 eq) and Bz2O2 (0.075 g, 0.31 mmol, 0.006 eq) at r.t. The reaction flask was vacuumed and backfilled by nitrogen. The reaction was stirred at reflux overnight. The reaction was cooled and stirred at r.t. Insoluble matter was removed by filtration. The filtrate was cooled with ice-water, and then filtered to give 2-bromo-3- (bromomethyl)benzonitrile (7.6 g, yield 54%): Purity by IH-NMR: 90%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 263159-64-4.
Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; ZHOU, Huchen; DING, Dazhong; ZHOU, Yasheen; ZHANG, Yong-Kang; PLATTNER, Jacob J.; WO2011/22337; (2011); A1;,
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