Application of 16588-02-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16588-02-6, name is 2-Chloro-5-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2-chloro-5-nitrobenzonitrile (2g,1 eq,10.96mmol), potassium carbonate (4.54g, 3eq, 32.7001), piperidine (1 ¡¤ 63 mL, 1.5 eq, 16.34 mmol) and DMF (5 mL) at 90 C Should be 3h, until the reaction is complete, remove the oil bath. DMF was diluted with 100 mL EA, washed with saturated ammonium chloride and sodium chloride respectively. The aqueous phase was extracted again with ethyl acetate. The organic phases were combined and dried over anhydrous sodium sulfate. The filtrate was concentrated to give a yellow solid (Compound 10) 2.528 g, yield 99%
The synthetic route of 2-Chloro-5-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Long Yaqiu; Xu Zhongliang; Wang Heyao; Cai Mengxin; (31 pag.)CN106892871; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts