Introduction of a new synthetic route about 170572-49-3

Electric Literature of 170572-49-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 170572-49-3, name is 3-Fluoro-4-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 3-fluoro-4-methylbenzonitrile (29.54 g) and NBS (46.7 g) as a suspension in 1,2-dichloroethane (500 ml) was treated with benzoyl peroxide (4.24 g) in a flask mounted with a reflux condenser open to air. The flask was immersed in an oil bath at 75 C and light shun on it with a sunlamp. A more vigorous reflux was suddenly observed and the reaction became homogeneous. The reaction was let stir at this temperature for a total of 2 hours then let cool to room temperature. Hexanes (500 ml) was added and the precipitate filtered and discarded. The filtrate was concentrated under reduced pressure to approximately 100 ml and taken up in ethyl acetate (200 ml). The reaction was washed with half saturated sodium bicarbonate (100 ml), then brine (100 ml). The organic layer was separated and dried over magnesium sulfate. The organic phase was concentrated under reduced pressure to give the benzylic bromide as a yellow solid that was used as such in the next step.

The chemical industry reduces the impact on the environment during synthesis 3-Fluoro-4-methylbenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2009/67797; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts