Some common heterocyclic compound, 623-03-0, name is 4-Chlorobenzonitrile, molecular formula is C7H4ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 623-03-0
General procedure: Microwave assisted reactions were carried out in a domestic microwave oven (Samsung-LCE 2733 GXTL) for realistic control of the microwaves operating at 850 W generating 2450MHz frequency through out the required time.A mixture of nitrile (0.01 mol), ethylenediamine (0.04 mol) and carbon disulphide solvent (0.001mol) was taken in a Erlenmeyer flask. The Erlenmeyer flask was placed in a microwave ovenand irradiated under at low power (100 W) for 30-150 seconds. The completion of the reactionwas monitored by TLC using ethyl acetate: methanol (4:1) as eluent. The reaction mixture wascooled at room temperature. Cold water (20 mL) was added to it and then extracted withchloroform (3 x 25 mL). The organic layer was dried over anhydrous Na2SO4 and evaporated.Crystallization of the crude product from cyclohexane gave the pure product in 70-80% yields(Table 1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 623-03-0, its application will become more common.
Reference:
Article; Pathan, Mohsin Y.; Paike, Vijaykumar V.; Pachmase, Pandurang R.; More, Sandeep P.; Ardhapure, Suresh S.; Pawar, Rajendra P.; ARKIVOC; vol. 2006; 15; (2006); p. 205 – 210;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts