Adding a certain compound to certain chemical reactions, such as: 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17823-40-4, Recommanded Product: 17823-40-4
A mixture of (1,2-dihydroacenaphthylen-5-yl)boronic acid (1.6 g, 8 mmol), 4-bromo-2,3,5,6-tetrafluorobenzonitrile (1.0 g, 3.9 mmol), Pd2(dba)3 (0.18 g, 0.20mmol), SPhos (0.16 g, 0.4 mmol), K3PO4 (2.0 g, 8.7 mmol) in toluene (50 mL) was degassed and heated at about 120 C for about 16 hours. After filtered off precipitate and washed with toluene, the filtrate was purified by flash column using eluents of hexane to hexane/dichloromethane (7:3). Removal of solvent give awhite solid (Compound 9) (0.54 g, in 42% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NITTO DENKO CORPORATION; ZHENG, SHIJUN; BASIAGO, ADAM; (86 pag.)JP2016/526025; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts